Investigating the Protective Effects of a Rhenium (V) Compound with Uracil-Derived Ligands on Liver Damage Associated with Prediabetes in Diet-Induced Prediabetic Rats

Non-alcoholic fatty liver disease (NAFLD) is associated with prediabetes and can be treated by using a combination of metformin dietary modification. However, people often fail to adhere modifications become more dependent on pharmaceutical intervention, this affects the effectiveness drug. In study, we investigated effects rhenium (V) compound uracil-derived ligands health in diet-induced prediabetic rats both presence absence Prediabetic male Sprague Dawley were for 12 weeks modification while monitoring fasting blood glucose levels. Antioxidant enzyme activity, inflammation markers enzymes measured together glycogen plasma triglycerides after sacrificing. The administration resulted reduced concentrations triglycerides. There was also glycogen, oxidative stress increasing antioxidant enzymes. Altogether, ameliorated injury prevented hepatotoxicity.